Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEGKNQTNISEFLLLGFSSWQQQQVLLFALFLCLYLTGLFGNLLILLAIGSDHCLHTPMYFFLANLSLVDLCLPSATVPKMLLNIQTQTQTISYPGCLAQMYFCMMFANMDNFLLT-------VMAYDRYVAICHPLHYSTIMALRLCASLVAAPWVIAILNPLLHTLMMAHLHFCSDNVIHHFFCDINSLLPLSCSDTSLNQLSVLATVGLIFVVPSVCILVSYILIVSAVMKVPSAQ-GKLKAFSTCGSHLALVILFYGAITGVYMSPLSNHSTEKDSAASVIFMVVAPVLNPFIYSLRNNELKGTLKKTLSRPGAVAHACNPSTLGGRGGWIMRSGDRDHPG 4LDL Chain:A ((197-403)) --------------------------------------VFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILTKTWTFG-------NFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQM--HWYRATHQEA------INCYAEETCCDFFTNQAYAIASSIVSFYVP----LVIMVFVYSRVFQEAKRQLQ---KFA-LKEHKALKTL--GIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCL------------------

General information: TITO was launched using: RESULT: Template: 4LDL.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -146537 for 1271 contacts (-115.3/contact) + 2D Compatibility (PS) -19978 + (NN) -7233 + (LL) 6240 1D Compatibility (HY) -15600 + (ID) 2950 Total energy: -186058.0 ( -146.39 by residue) QMean score : 0.234

(partial model without unconserved sides chains): PDB file : Tito_4LDL.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4LDL-query.scw PDB file : Tito_Scwrl_4LDL.pdb: