Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MDEQSQGMQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIE--DNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKRMHACTASS 2W5B Chain:A ((7-262)) --------------------------------DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQM-LVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRS-LHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTA--FSQKELAGKIREGKFRRIPY-RYSDELNEIITRMLNLKDYHRPSVEEILENPLILEHHHHHH

General information: TITO was launched using: RESULT: Template: 2W5B.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -147978 for 1870 contacts (-79.1/contact) + 2D Compatibility (PS) -26893 + (NN) -17246 + (LL) 1272 1D Compatibility (HY) -24400 + (ID) 4700 Total energy: -219945.0 ( -117.62 by residue) QMean score : 0.535

(partial model without unconserved sides chains): PDB file : Tito_2W5B.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2W5B-query.scw PDB file : Tito_Scwrl_2W5B.pdb: