Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MSVISIILVVLIAFLAGIEGILDEFQFHQPLIACTLIGLVTGNLTACIILGGTLQMIALG---WANIGAAVAPDAALASVASAIILVLGGQGVAGIPSAIAIAIPLAVAGLFLTMIVRTLAVPIVHLMDRAAEKGNIRSVEWLHISAICMQGVRIAIPAAALLFIPADSVQSFLEAMP-AWLTDGMAIGGGMVVAVGYALVINMMATKEVWPFFVIGFVVAAISQLTLIAIGALGVALALIYLNLSKMGGGNSNGGGGGNSRDPLGDILNDY--------------- 4Q0S Chain:A ((12-260)) SARTSITRREYDEWVREAAALGKALRYP--------ITEKMVNDSAGIVFG-ADQYDAFKNGMWSGE----------PYEAMIIFESLNEPAVDGLPTGAAPYAEYS-GLCDKLMIVHPGKFCPPHHHGRKT------------------ESYEVVLGEMEVFYSPTPSAESGVELLNFSGMPVGSPWPEGVALPKGRESSYEKLTSYVRLRAGDPKFVMHRKHLHAFRCPPDSDVPLVVREVSTYSHEPTEAAAGNHAPIPSWLGMHDNDFVSDAANTGRLQTAIS

General information: TITO was launched using: RESULT: Template: 4Q0S.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -232857 for 1747 contacts (-133.3/contact) + 2D Compatibility (PS) -23581 + (NN) 5149 + (LL) 3160 1D Compatibility (HY) 2800 + (ID) 1900 Total energy: -247229.0 ( -141.52 by residue) QMean score : 0.125

(partial model without unconserved sides chains): PDB file : Tito_4Q0S.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4Q0S-query.scw PDB file : Tito_Scwrl_4Q0S.pdb: