Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP--RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1OIT Chain:A ((3-291)) -----------NFQKVEKIGEGTYGVVYKARN-KL-GEVVALKKI-----------TAIREISLLKELN---HPNIVKLLDVIHT-----ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLSFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARA----------VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------

General information: TITO was launched using: RESULT: Template: 1OIT.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -181892 for 2069 contacts (-87.9/contact) + 2D Compatibility (PS) -27377 + (NN) -10432 + (LL) 2888 1D Compatibility (HY) -32400 + (ID) 6950 Total energy: -256163.0 ( -123.81 by residue) QMean score : 0.734

(partial model without unconserved sides chains): PDB file : Tito_1OIT.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1OIT-query.scw PDB file : Tito_Scwrl_1OIT.pdb: