Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGVSFQSTDEAFLIIGTFVRAV--FIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAKLMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAGTSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYMAIRNADKQDA 1IOW Chain:? ((97-306)) -------KLRSKLLWQGAGLPVAPWVALTRAEFEKGLSDKQLAEISALGLPVIVKPSREGSSVGMSKVVAENALQDALRLAFQHDEEVLIEKWL--SGPEFTVAILGEEILPSIRIQPSGTFYDYEAKFLSDETQYFCPAGLEASQEANLQALVLKAWTTLGCK--------GWGRIDVMLDSDGQFYLLEANTSPGMTSHS--LVPMAARQAGMSFSQLVVRILELAD-

General information: TITO was launched using: RESULT: Template: 1IOW.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 941 -148723 -158.05 -715.01 target 2D structure prediction score : 0.41 Monomeric hydrophicity matching model chain A : 0.61 3D Compatibility (PKB) : -158.05 2D Compatibility (Sec. Struct. Predict.) : 0.41 1D Compatibility (Hydrophobicity) : 0.61 QMean score : 0.129

(partial model without unconserved sides chains): PDB file : Tito_1IOW.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1IOW-query.scw PDB file : Tito_Scwrl_1IOW.pdb: