Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence -------------------------MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLISLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSI------------TLDKQKKEDLHVR-------------- 1DVK Chain:A ((79-247)) MRIQEAIAQDKTISVIIDPSQIGSTEGKPLLSMKCNLYIHEILSRWKASLEA---YHPELFLDTKKALFPLLLQLRRNQLAPDLLISLATVLYHLQQPKEINLAVQSYMKLSIGNVAWPIGVANIMIDERTRLWITSIKRLITFEEWYTSNH

General information: TITO was launched using: RESULT: Template: 1DVK.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 261 -21474 -82.27 -219.12 target 2D structure prediction score : 0.77 Monomeric hydrophicity matching model chain A : 0.61 3D Compatibility (PKB) : -82.27 2D Compatibility (Sec. Struct. Predict.) : 0.77 1D Compatibility (Hydrophobicity) : 0.61 QMean score : 0.304

(partial model without unconserved sides chains): PDB file : Tito_1DVK.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1DVK-query.scw PDB file : Tito_Scwrl_1DVK.pdb: