Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIRPGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGL-PFSITI-------GHELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEFANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSLFIGAIQAFIFTMLTMVYMSHKISHDH 1C17 Chain:M ((98-265)) -----------------------------------------------------------------------SKLIAPLALTIFVWVFLMNLMDLLPIDLLPYIAEHVLGLPALRVVPSADVNVTLSMALGVFILILFYSIKMK----------------------SLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWW-------------SQWILNVPWAIFHILIITLQAFIFMVLTIVYLS-------

General information: TITO was launched using: RESULT: Template: 1C17.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain M - contact count / total energy / energy per contact / energy per residue : 339 -64883 -191.40 -495.29 target 2D structure prediction score : 0.72 Monomeric hydrophicity matching model chain M : 0.63 3D Compatibility (PKB) : -191.40 2D Compatibility (Sec. Struct. Predict.) : 0.72 1D Compatibility (Hydrophobicity) : 0.63 QMean score : 0.138

(partial model without unconserved sides chains): PDB file : Tito_1C17.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1C17-query.scw PDB file : Tito_Scwrl_1C17.pdb: