Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQDALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAGAELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVADEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDDFEEVYNTWQN----------WAPYTDDRLTSSIEFWPKEVNR---IEALGQFVGPKTELKKLLKPLLKAGSPTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQNASVWQQA---LGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWI-EGLRTSLSKETMGDYVNWPDIEIRNWPRTYYG-ENVERLRRVKTTYDPENVFRFEQSIPPLRRSLFF 3W8X Chain:B ((24-465)) -------GELIWPSDADYDEARRIWNGTIDRRPALIARCTSTPDVVAAVSFARKSGLLVAVRGGGHSMAGHSVCDGGIVIDLSLMNSIKVSRRLRRARAQGGCLLGAFDTATQAHMLATPAGVVSHTGLGGLVLGGGFGWLSRKYGLSIDNLTSVEIVTAD----GGVLTASDTENPDLFWAVR-GGGGNFGVVTAFEFDLHRVGPVRFASTYYSLDEGPQVIRAWRDHMATAPDELTWALYL--RLAPPLPELPADMHGKPVICAMSCWIGDPHEGERQLESILHAGKP-HGLTKATLPYRALQAYSFPGAVVPDRIYTKSGYLNE-LSDEATDTV---LEHAADIASPFTQLELLYLGGAVARVPDDATAYPNRQSPFVTNLAAAWMDPTEDARHTAWAREGYR-ALAGHLSGGYVNFMNPGEADRTREAYGAAKFERLQGVKAKYDPTNLFRLNQNIPP-------

General information: TITO was launched using: RESULT: Template: 3W8X.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain B - contact count / total energy / energy per contact / energy per residue : 2559 -198299 -77.49 -467.69 target 2D structure prediction score : 0.58 Monomeric hydrophicity matching model chain B : 0.79 3D Compatibility (PKB) : -77.49 2D Compatibility (Sec. Struct. Predict.) : 0.58 1D Compatibility (Hydrophobicity) : 0.79 QMean score : 0.446

(partial model without unconserved sides chains): PDB file : Tito_3W8X.pdb: (Unconserved sides chains are recalculated) : Sequence: align-3W8X-query.scw PDB file : Tito_Scwrl_3W8X.pdb: