Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDT-VRGRLIDVKPD-HITIEGAR------------NSVCLIRIQHMISVTPDYSERV 4XQ3 Chain:A ((10-79)) ------------------KSLRTAINRIVLVKLKDGSEYIGKLEQTDGTMNLVLRDCTEIREGTSEPVAKYGRVLIRGSNILFISVDY----

General information: TITO was launched using: RESULT: Template: 4XQ3.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 166 -15648 -94.26 -279.42 target 2D structure prediction score : 0.46 Monomeric hydrophicity matching model chain A : 0.65 3D Compatibility (PKB) : -94.26 2D Compatibility (Sec. Struct. Predict.) : 0.46 1D Compatibility (Hydrophobicity) : 0.65 QMean score : 0.628

(partial model without unconserved sides chains): PDB file : Tito_4XQ3.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4XQ3-query.scw PDB file : Tito_Scwrl_4XQ3.pdb: