Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKLSELLSAYSIETEFSNDFEVHALAELDKATPNDISYIDQVCYLKLLKDSKAGAVFIRKKESSKVPKSMQALIVDNPHLAFAKVSHAFKIPFFKNPQSVNEPKH-----FEKVTIMPNVVIGEGVEIGENSLIYPGVVIADGVKIGKNCILYPRVILYQNTILEDNVIIHAGSVIGGDGFGYAHTALGEHVKIEHVGIVRIQKNVEIGANTAIDRAVFGETLIKEGVKIDNLVQIGHNCVLGEHSIVVSQVGLSGSTTTGRNVVFGGQVGIGGHLHVGEFTQIGGKSAVGKDLPPNTNFAGAIPAMEIHEWHHFLAHLRTNFRKQQKTSLLQKAKGFFKS 4E75 Chain:A ((28-326)) --------------QFSN------LASLENAEVNHLTFVNGEKHLDQAKVSRAGAYIVTAALKEHLPEKDNFIIVDNPYLAFAILTHVFDKKISSTGIESTARIHPSAVISETAYIGHYVVIGENCVVGDNTVIQSHTKLDDNVEVGKDCFIDSYVTITGSSKLRDRVRIHSSTVIGGEGFGFAPYQ-GKWHRIAQLGSVLIGNDVRIGSNCSIDRGALDNTILEDGVIIDNLVQIAHNVHIGSNTAIAAKCGIAGSTKIGKNCILAGACGVAGHLSIADNVTLTGMSMVTKNISEAGTYSSGTGLFENNHWKKTIVRLRQLADVPLTQITKRLD------

General information: TITO was launched using: RESULT: Template: 4E75.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -210517 for 2288 contacts (-92.0/contact) + 2D Compatibility (PS) -32683 + (NN) -15735 + (LL) 2520 1D Compatibility (HY) -18800 + (ID) 5000 Total energy: -280215.0 ( -122.47 by residue) QMean score : 0.385

(partial model without unconserved sides chains): PDB file : Tito_4E75.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4E75-query.scw PDB file : Tito_Scwrl_4E75.pdb: