Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRRLPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFT-GSLYSMKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIA-----TKA-AR---------IKG---VI--GDEVALEFGTRRAHEM---DAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYR--------DEYTAFKKYAETH-K-DCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKARKMLDEAGFT--DAKVIASSDLDEHTIMNLKA--QGARIDVWGVGTKLITAYDQ-PALGAVYKLVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQKRLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEEYKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE 1YIR Chain:A ((12-392)) -------IVQNLLDTDFYKLTMMQAVLHNYP-NAEVEWEFRCRNQEDL--RLYLPAIREQLEYLAGLAISDEQLAFLERIPFLAPDFIRFLGLFRFNPRYVQTGIE-----NDEFFLRLKGPWLHVILFEVPLLAMISEVRNRARYPAATVEQARERLQEKFDWLRREASAEELAGFKMADFGTRRRFSYRVHEAVVSGLKEDFPGCFVGTSNVHLARKLDLKPLGTMAHEWLMAHQQLGPRLIDSQSAALDCWVREYRGLLGIALTDCITTDA-FLRDFDLY-----FAKLFDGLRHDSGDPLLWAEKTIAHYLKLGIDPLTKTLVFSDGLDLPRALKIYRALQGRINVSFGIGTHFTCDLPGVEPMNIVVKMSACNG----HPVAKISDTP-------PDFIHY---------------------------------------------------------------------------------------------------------------------------

General information: TITO was launched using: RESULT: Template: 1YIR.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1645 -61300 -37.26 -182.98 target 2D structure prediction score : 0.57 Monomeric hydrophicity matching model chain A : 0.65 3D Compatibility (PKB) : -37.26 2D Compatibility (Sec. Struct. Predict.) : 0.57 1D Compatibility (Hydrophobicity) : 0.65 QMean score : 0.504

(partial model without unconserved sides chains): PDB file : Tito_1YIR.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1YIR-query.scw PDB file : Tito_Scwrl_1YIR.pdb: