Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MHTCPRCDSKKGEVMSKSP--VEG-------AWEVYQCQTCFFTWRSCEPESITNPEKYNPAFKIDPKETETAIEVPAVPERKA 1TVS Chain:? ((1-75)) -LEDRRIPGTAEENLQKSSGGVPGQNTGGQEARPNYHCQLCFLRSL--------GIDYLDASLRKKNKQRLKAIQQGRQPQYLL

General information: TITO was launched using: RESULT: Template: 1TVS.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 90 5994 66.59 90.81 target 2D structure prediction score : 0.76 Monomeric hydrophicity matching model chain A : 0.65 3D Compatibility (PKB) : 66.59 2D Compatibility (Sec. Struct. Predict.) : 0.76 1D Compatibility (Hydrophobicity) : 0.65 QMean score : 0.132

(partial model without unconserved sides chains): PDB file : Tito_1TVS.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1TVS-query.scw PDB file : Tito_Scwrl_1TVS.pdb: