Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence -MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRL-AGQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGLSVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDVSKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQLALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYR--STKEIEHVLNHEESMLYKPWQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNKEYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQYKQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFDYAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEE--DQYDIHWLDDMVFQQDYKEPSLVKRLFRTITQK 4UUW Chain:A ((1-394)) MERAEILGVG---------TELLYGETLDTNTAEIARSLKPYALKVERTLRVADEVAPLAREVEEAFARARLVVLSGGLGPT-------------------PDDVTREAVALALGEPL-----------ELDEAVLGEIEAFFRARGRAMPEANRKQAMR----------------------IPSATWLKNPRGTAP--GWWVRKGGKDLVLL------------PGPPPEWRPMWQEVLPRLGLPR-RPYAERVLKTWGIGESEIVERLGPL---------FVREEEVEVGTYPKVHGVEVVVRGR--------EDRVAELAERIKKKLL------KEVWGE-------------GEMTLAEAVKRRMEREGATLSTMES-----------------LTGG---LLGAEITRV---PGASRFYLGGVVSYS-VGAKARFGVPQDLLSRTVSAETARAMAEAARSLFGSTYALATTGVA--------GPDPLEGEPPGTVYVALAGPTGAEVRRYRFPGD---RETVRLRSVYAALALLVT--

General information: TITO was launched using: RESULT: Template: 4UUW.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 2077 -122157 -58.81 -314.84 target 2D structure prediction score : 0.51 Monomeric hydrophicity matching model chain A : 0.65 3D Compatibility (PKB) : -58.81 2D Compatibility (Sec. Struct. Predict.) : 0.51 1D Compatibility (Hydrophobicity) : 0.65 QMean score : 0.202

(partial model without unconserved sides chains): PDB file : Tito_4UUW.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4UUW-query.scw PDB file : Tito_Scwrl_4UUW.pdb: