Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQLVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEP-------AKRELWIRIRDAVKEVLDSTTLEDLASYTDGEQ--EAYMFYI 4CIC Chain:B ((5-152)) LKVSTKGHYGVQAMFDLAQHFGEGPVSLKSIAERQGLSEPYLEQLIAVLRKAGLVKSVRGAQGGYILAREPRDIKVGDIIRVLEG-------------SLKFDFSVTKSVWEKVKKSIEEVLDSITLADMLKDAEEAQMAQGYMYY-

General information: TITO was launched using: RESULT: Template: 4CIC.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain B - contact count / total energy / energy per contact / energy per residue : 412 -46880 -113.79 -378.06 target 2D structure prediction score : 0.69 Monomeric hydrophicity matching model chain B : 0.82 3D Compatibility (PKB) : -113.79 2D Compatibility (Sec. Struct. Predict.) : 0.69 1D Compatibility (Hydrophobicity) : 0.82 QMean score : 0.526

(partial model without unconserved sides chains): PDB file : Tito_4CIC.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4CIC-query.scw PDB file : Tito_Scwrl_4CIC.pdb: