Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDLAK------AFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKY-SRELSLLAGLMIFIIGTVICALAQ--NIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPY--TYRGKVMGLIVSSWSLALIFGVPLGSFIGGVLHWRWTFWIFALMGVLVVLLILL-EMRRHAQHKNSGK-E-EI-E--EPAGT----------------------------------------------------FRDALKVPRVPV----YITITFCNMIGFYGMYSFLGTYLQDVFTGG----NTAAGLFIMIYGIG-FSMSVITGKIADRIGKMRS------LLIALGVISVLLACLPYAP----------ASMFLLIASLFIWGLMQSLTVTLLSTILSDCSE-RHRGKVMVFYSLASNLAVTLGSALMGPVYVA--YGYAAVGLICAAITVLGFVLSVFAYKKYGKLEQKADQSLSQ 4W6V Chain:A ((20-491)) -------------------LSGLFLSEMWERFSFYGIRPLLILFMAATVFDGGMGLPREQASAIVGIFAGSMYLAALPGGLLADNWLGQQRAVWYGSILIALGHLSIALSAFFGNDLFFIGLVFIVLGTGLFKTCISVMVGTLYKPGDARRDGGFSLFYMGINMGSFIAPLLSGWLLRTHGWHWGFGIGGIGMLVALLIFRGFAIPAMKRYDAEVGLDSSWNKPT-----GRWVTAIMAVVVVIIALISQGVIPINPVMIASLLVYVIAASVTLYFIYLFAFAKMSRKDRARLLVCFILLVSAAFFWSAFEQKPTSFNLFANDYTDRMVMGFEIPTVWFQSINALFIILLAPVFSWA---------PSSITKFVIGILCAAAGFAVMMYAAQHVLSSGGAGVSPLWLVMSILLLTLGELCLSPIGLATMTLLAPDRMRGQVMGLWFCASSLGNLAAGLIGGHVKADQLDMLPTLFARCSIALVICAAVL--------------------

General information: TITO was launched using: RESULT: Template: 4W6V.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1384 -190684 -137.78 -531.15 target 2D structure prediction score : 0.54 Monomeric hydrophicity matching model chain A : 0.62 3D Compatibility (PKB) : -137.78 2D Compatibility (Sec. Struct. Predict.) : 0.54 1D Compatibility (Hydrophobicity) : 0.62 QMean score : 0.262

(partial model without unconserved sides chains): PDB file : Tito_4W6V.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4W6V-query.scw PDB file : Tito_Scwrl_4W6V.pdb: