Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDT-VRGRLIDVK-PDHITIEG-----AR-------------NSVCLIRIQHMISVTPDYSERV 4C92 Chain:E ((9-85)) -----------------LEVIDKTINQKVLIVLQSNREFEGTLVGFDDFVNVILEDAVEWLIDPEDESRNEKVMQHHGRMLLSGNNIAILVPGG----

General information: TITO was launched using: RESULT: Template: 4C92.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain E - contact count / total energy / energy per contact / energy per residue : 149 -13177 -88.43 -231.17 target 2D structure prediction score : 0.54 Monomeric hydrophicity matching model chain E : 0.66 3D Compatibility (PKB) : -88.43 2D Compatibility (Sec. Struct. Predict.) : 0.54 1D Compatibility (Hydrophobicity) : 0.66 QMean score : 0.579

(partial model without unconserved sides chains): PDB file : Tito_4C92.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4C92-query.scw PDB file : Tito_Scwrl_4C92.pdb: