Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDS-----IPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 4EOM Chain:A ((5-300)) MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRL--ETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLSMDLKKFMDASALTGIP------LPLIKSYLFQLLQGLAFCHSHRVLHRDLKPENLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL

General information: TITO was launched using: RESULT: Template: 4EOM.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -172715 for 2263 contacts (-76.3/contact) + 2D Compatibility (PS) -29914 + (NN) -8213 + (LL) 108 1D Compatibility (HY) -40000 + (ID) 9850 Total energy: -260584.0 ( -115.15 by residue) QMean score : 0.504

(partial model without unconserved sides chains): PDB file : Tito_4EOM.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4EOM-query.scw PDB file : Tito_Scwrl_4EOM.pdb: