Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFGAYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYE--LVINSDPCYAFLLDSNSLIQNKLIVAHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQEHIDPSLVRPKLQWSVDDEEEEIEEAA-TPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKDILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLTSDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGREKMFEVREIESDISFIRN---YLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRVNGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEK---VLPYLFQLWGRSVHIESVLEDKEVMFSYDGKGVHRRYL 2QMI Chain:A ((1-447)) ---MDVGKLESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSL--------GYAEAFIDGMVGGDNWLPVSTPEETIAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADGGLLS--------SVLDLAKYLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLG------EKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYPPSYIAMYALALLLGKNPEKELPFIYRERILKKVEGRYMGYKGTIKFEVKVDG--DVVYLRALGRAFTYTIPLFPEVLEEDFIKCYTLSNGRKMYAEFYIKDNKVDLIFERYRLIKS--

General information: TITO was launched using: RESULT: Template: 2QMI.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 2475 -184447 -74.52 -421.11 target 2D structure prediction score : 0.44 Monomeric hydrophicity matching model chain A : 0.60 3D Compatibility (PKB) : -74.52 2D Compatibility (Sec. Struct. Predict.) : 0.44 1D Compatibility (Hydrophobicity) : 0.60 QMean score : ?

(partial model without unconserved sides chains): PDB file : Tito_2QMI.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2QMI-query.scw PDB file : Tito_Scwrl_2QMI.pdb: