Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MSKLDEMTAYLPPFLTKLKEMAELLKAEAPEFEKQNNSIFDLTDQLFVTTATWGLERWEKILNVPRESGDTDEIRRLRLISKMSNIPPATYRAIEHALNRFLKNPSAQVRLLPGEYRFKVDIDIDDMQHMSELIETLENMKPAHLAYTLRAALNEPLQIKDTVILNNRRYRKASELKVGYSVTLNNNEVVLV--- 1XI0 Chain:A ((3-145)) MSYSITLRVYQTN-----RDRGYFSIVEKTVWHFANGG-------------TWSEANGAHTLTQGGSGT--------------------------SGVLRFLSTKGERITVAVGVHNYKRWCDVVTGLKPDE---TALVINPQYYNNGGRDYVREKQLAEYSVTSAIGT-----KVEVVYTVAEGNNLEANVIFS

General information: TITO was launched using: RESULT: Template: 1XI0.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 760 -20503 -26.98 -146.45 target 2D structure prediction score : 0.31 Monomeric hydrophicity matching model chain A : 0.58 3D Compatibility (PKB) : -26.98 2D Compatibility (Sec. Struct. Predict.) : 0.31 1D Compatibility (Hydrophobicity) : 0.58 QMean score : 0.078

(partial model without unconserved sides chains): PDB file : Tito_1XI0.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1XI0-query.scw PDB file : Tito_Scwrl_1XI0.pdb: