Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKKAYLTVCSNQQIADRVFQMVLKGEL--VQGFTTPGQFLHLKVSEAVTPLLRRPISIADVNFEKNEVTIIYRVD--GEGTRLLS-LKQQGELVDVLGPLGNGFPVNEVQPGKTALLVGGGVGVPPLQELSKRLIEK--GVNVIHVLGFQSAKDVFYEEECRQYGD----TY---VATA-DGSYGETGFVTDVIKRK--KLEFDILLSCGPTPMLKALKQEYA--HKE-VYLSMEERMGCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL 1KRH Chain:A ((108-334)) --HFEGTLARVENLSDSTITFDIQLDDGQPDIHFLAGQYVNVTLPG---TTETRSYSFSSQPG-NRLTGFVVRNVPQGKMSEYLSVQAKAGDKMSFTGPFGSFYLR-DV--KRPVLMLAGGTGIAPFLSMLQVLEQKGSEHPVRLVFGVTQDCDLVALEQLDALQQKLPWFEYRTVVAHAESQHERKGYVTGHIEYDWLNGGEVDVYLCGPVPMVEAVRSWLDTQGIQPANFLFEK----------------------------------------

General information: TITO was launched using: RESULT: Template: 1KRH.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1127 -125309 -111.19 -605.36 target 2D structure prediction score : 0.53 Monomeric hydrophicity matching model chain A : 0.66 3D Compatibility (PKB) : -111.19 2D Compatibility (Sec. Struct. Predict.) : 0.53 1D Compatibility (Hydrophobicity) : 0.66 QMean score : 0.487

(partial model without unconserved sides chains): PDB file : Tito_1KRH.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1KRH-query.scw PDB file : Tito_Scwrl_1KRH.pdb: