Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP--RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4FKQ Chain:A ((5-292)) ----------ENFQKVEKIGEGTYGVVYKARN-KLTGEVVALKKIRL------VPSTAIREISLLKELN---HPNIVKLLDVIHT-----ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG--------VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------

General information: TITO was launched using: RESULT: Template: 4FKQ.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) 8710 for 2135 contacts (4.1/contact) + 2D Compatibility (PS) -27314 + (NN) 148 + (LL) 2504 1D Compatibility (HY) 18800 + (ID) 950 Total energy: 1898.0 ( 0.89 by residue) QMean score : 0.146

(partial model without unconserved sides chains): PDB file : Tito_4FKQ.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4FKQ-query.scw PDB file : Tito_Scwrl_4FKQ.pdb: