Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFKDTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWDGVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGIDQFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTG--TRLTDMGLGWFVGFIKTEHGSYVFVTNVD----DSGTKAKNITVDILKKYGLITS 4WMC Chain:F ((17-241)) ---------------------------------------------SQGVVVLWNENKQQGFTNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRD-ATWNRDHNLITAMKYSVVPVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATEQISFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYSTRI-EPKIGWWVGWVELDDNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKII--

General information: TITO was launched using: RESULT: Template: 4WMC.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain F - contact count / total energy / energy per contact / energy per residue : 1126 -124863 -110.89 -572.76 target 2D structure prediction score : 0.64 Monomeric hydrophicity matching model chain F : 0.75 3D Compatibility (PKB) : -110.89 2D Compatibility (Sec. Struct. Predict.) : 0.64 1D Compatibility (Hydrophobicity) : 0.75 QMean score : 0.520

(partial model without unconserved sides chains): PDB file : Tito_4WMC.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4WMC-query.scw PDB file : Tito_Scwrl_4WMC.pdb: