Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQDALNALKWARENRVPFRIRGGRHSYENFSLL-NNGLVIDLSEMKKITVNQDKKLAYIEAGAELGEVYRTLWQ-YGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIV--ADEKEGADLITVS-----CSNHPDLFWASQGGGGGNFGIVTSMTFKAVPIS------------Q--VSIFSITWGWDD-----FEEVYNTWQNWAPY--TDD----RLTSSIEFWPK--EVNRIEALGQFVGPKTELKKLLKPLLKAGSP-----TSGMVKTTPFIEAVTFFNS-PGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAP--NQNASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSLSKE----------TMGDYVNWPDIEIR---------NWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLFF 2Y3S Chain:A ((34-529)) -------IDSVAPGDIRYEDLRRGENLRFVGDPEEIHLVGSAAEIEQVLSRAVRSGKRVAVRSGGHCYEDFVANSDVRVVMDMSRLSAVGFDEERGAFAVEAGATLGAVYKTLFRVWGVTLPGGACPDVGAGGHILGGGYGPLSRMHGSIVDYLHAVEVVVVDASGD----ARTVIATREPSDPNHDLWWAHTGGGGGNFGVVVRYWLRTAEADVPPEPGRLLPRPPAEVLLNTTVWPWEGLDEAAFARLVRNHGRWFEQNSGPDSPWCDLYSVLALTRSQSGALAMTTQLDATGPD--AEKRLETYLAAVSEGVGVQPHSDTRRLPWLHSTRWPGIAGDGDMTGRAKIKAAYARRSFDDRQIGTLYTRLTSTDYDNPAGVVALIAYGGKVNAVPADRTAVAQRDSILKIVYVTTWEDPAQDPVHVRWIRELYRDVYADTGGVPVPGGAADGAYVNYPDVDLADEEWNTSGVPWSELYYKDAYPRLQAVKARWDPRNVFRHALSVRVPP-----

General information: TITO was launched using: RESULT: Template: 2Y3S.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 2525 -199092 -78.85 -459.80 target 2D structure prediction score : 0.58 Monomeric hydrophicity matching model chain A : 0.72 3D Compatibility (PKB) : -78.85 2D Compatibility (Sec. Struct. Predict.) : 0.58 1D Compatibility (Hydrophobicity) : 0.72 QMean score : 0.441

(partial model without unconserved sides chains): PDB file : Tito_2Y3S.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2Y3S-query.scw PDB file : Tito_Scwrl_2Y3S.pdb: