Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEDYIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQFMDSSLVKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWK-PGSLASHVKNLDENGLDLLSKMLVYDPAKRISGKMALKHPYFDDLDNQIKKM 4AU8 Chain:A ((6-293)) -QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV---------PSSALREICLLKELKHKNIVRLHDVLH---KLTLVFEFCDQDLKKYFDSCN--GDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR--SAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP-YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF-------

General information: TITO was launched using: RESULT: Template: 4AU8.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -157418 for 2219 contacts (-70.9/contact) + 2D Compatibility (PS) -28418 + (NN) -9810 + (LL) 1436 1D Compatibility (HY) -31200 + (ID) 8000 Total energy: -233410.0 ( -105.19 by residue) QMean score : 0.487

(partial model without unconserved sides chains): PDB file : Tito_4AU8.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4AU8-query.scw PDB file : Tito_Scwrl_4AU8.pdb: