Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEFEDKWK-SRS---LKGVFVAQDEKGSVFGFASFGPIRSE---------------------------QEGYDGELYAIYLLEERQRQGAGRALLAKGAEFLLQHGFSSMFVWVIEQN-PSIIFYQAYSPERVAEDNFEIAGVRLKEVGLGWPDLSALKTLLNR 1U6M Chain:A ((2-177)) -SLIRSATKEDGQAIARLVLVILKDMELPILEEVSEEQMI-DLLAEATAYPTYRYGYQRILVYEH-AGEVAGIAVGYPAEDEKIIDEPLREVFKKHGLAEDVRLFIEEETLPNEWYLDTISVDERFRGMGIGSKLLDALPEVAKASGKQALGLNVDFDNPGARKLYASKGFKDVTTMTI--------------------------

General information: TITO was launched using: RESULT: Template: 1U6M.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 612 -14514 -23.71 -100.79 target 2D structure prediction score : 0.61 Monomeric hydrophicity matching model chain A : 0.61 3D Compatibility (PKB) : -23.71 2D Compatibility (Sec. Struct. Predict.) : 0.61 1D Compatibility (Hydrophobicity) : 0.61 QMean score : 0.429

(partial model without unconserved sides chains): PDB file : Tito_1U6M.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1U6M-query.scw PDB file : Tito_Scwrl_1U6M.pdb: