Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MLYTMKDLLAVGKEHQFAVPAFNICSFDMLKAIMEEVEANNAPVILEIHPDEIEYLGDNFVATVREYAYRSK--VPVVIHMDHGGTIKDVMRAIRNGYTSVMIDASRASYEENVALTTQVVELAHKVGVSVEAELGTIGNNGSAEGGADTIIYTDPDQAEDFVSRTGIDTLAVAIGTAHGLYPKDKKPELNMPL--LKELNKRLDIPFVLHGGS---------------------GNPDKEVSESVQYGVRKVNLSSDLKSVFFEEVRRVLVDNPAMYEPNQVYPSANEKVKDVVRHKLDILNTTGQADKY 2ISV Chain:B ((3-310)) -LCTLRQMLGEARKHKYGVGAFNVNNMEQIQGIMKAVVQLKSPVILQCSRGALKYSDMIYLKKLCEAALEKHPDIPICIHLDHGDTLESVKMAIDLGFSSVMIDASHHPFDENVRITKEVVAYAHARSVSVEAELG-----------QNTVQLTEPQDAKKFVELTGVDALAVAIGTSHGAYKF-----IRLAIDRVKTISDLTGIPLVMHGSSSVPKDVKDMINKYGGKMPDAVGVPIESIVHAIGEGVCKINVDSDSRMAMTGAIRKVFVEHPEKFDPRDYLGPGRDAITEMLIPKIKAFGSAGHAGDY

General information: TITO was launched using: RESULT: Template: 2ISV.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -129168 for 2388 contacts (-54.1/contact) + 2D Compatibility (PS) -29731 + (NN) -14812 + (LL) -148 1D Compatibility (HY) -26400 + (ID) 4800 Total energy: -205059.0 ( -85.87 by residue) QMean score : 0.627

(partial model without unconserved sides chains): PDB file : Tito_2ISV.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2ISV-query.scw PDB file : Tito_Scwrl_2ISV.pdb: