Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEKIES-VLNEPMRIICTNGTISQL--RLEELADE-LYDKDVYILVDADESGEKLRKQLKREFNE--ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV 1Q57 Chain:A ((134-237)) ---------GSHKSDALFGKHLWN----GGKKIVVTEGEIDMLTVMELQDCKY-PVVSLGHGASAAKKTCAANYEYFDQFEQIILMFDMDEAGRKAVEEAAQVLPAGKVRVAVLP-------------------------------------

General information: TITO was launched using: RESULT: Template: 1Q57.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 422 3801 9.01 40.01 target 2D structure prediction score : 0.39 Monomeric hydrophicity matching model chain A : 0.58 3D Compatibility (PKB) : 9.01 2D Compatibility (Sec. Struct. Predict.) : 0.39 1D Compatibility (Hydrophobicity) : 0.58 QMean score : 0.320

(partial model without unconserved sides chains): PDB file : Tito_1Q57.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1Q57-query.scw PDB file : Tito_Scwrl_1Q57.pdb: