Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARRSQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQYGTFGQLYYL-LGFHHLYGSWWYLLLIASIGIS---LVICSLDRVIPLYRALKNQGVRRSPAFLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHIGLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEKKVFADAIDRVGDGRVAKNFQTDAVLYKREGK-IVYGEKPKLEKVTEEDIRVNQPLRFDSFSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLPDFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNK-YKLKFDHVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQ-GMYWQHRRIWLHSQDGAVMVAGHTNKNW--FGLKKD-----LAFILADSGLTEPVDQKELIKTQK 3FHC Chain:A ((9-405)) IPEREMKDFQFRALKKVRIFDSPEELPKERSSL--------LAVSNKYG--------------------LVFAGGASGL-QIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFD-----VRTFSNEAQKRPF------------------------------AYHKLLKDAGGM------------------------------VIDMKWNPTV----PSMVAVCLADGSIAVLQVTETVKVCATLPSTVA------------------VTSVCWSPKGKQLAVGKQN---------------------------------GTVVQYLPTLQEKKVIPCPPF--------YESDHPVRVLDVLWIGTYVFAIVYAAADGT-LETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEW---------DLVLAASAASTEVSILARQSDQINWESWL--LEDSSRAELPVTDKSDDSLPMGVVVDYTNAPVLMLLSTDGVLCPFYMIN------

General information: TITO was launched using: RESULT: Template: 3FHC.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 2078 -25162 -12.11 -68.56 target 2D structure prediction score : 0.43 Monomeric hydrophicity matching model chain A : 0.63 3D Compatibility (PKB) : -12.11 2D Compatibility (Sec. Struct. Predict.) : 0.43 1D Compatibility (Hydrophobicity) : 0.63 QMean score : 0.262

(partial model without unconserved sides chains): PDB file : Tito_3FHC.pdb: (Unconserved sides chains are recalculated) : Sequence: align-3FHC-query.scw PDB file : Tito_Scwrl_3FHC.pdb: