Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MANEHLNLFSLENSDYIYADYNATFPVSDSVKESILEVLSKQVLNPSSLHRKGQEARRILQDARDNIRSAIGVPSNKEIVFTSGATEANSLVMKGIA------GFQHVISAVEHPSILNSA-------CNPHIIPVNQGGIVDLLALERILSELKGNRVIVSVMMANNETGVVQPVKEIAEIAHKFETIYHTDAAQSVGKIKVNMEDLGMDLLTLSAHKFGGIAGSGVLIFNKDLVIEPIIVGGGQEKGLRGGTENIVAIAGLSAALQSISNLLSKMDEIKELRDQLEYELLNLASGIKIF-----GKNSKRLPNTSLIYMPGVKSDVQLMNFDLNNIAVSNGSACSSGKVEPSHVLLAMGATREQAECSIRVSIGPQTKPRDIRKIVDCWYNIYEKNILDMRK 4HVK Chain:A ((3-372)) -----------------YFDYTSAKPVDERILEAMLPYMTESFGNPSSVHSYGFKAREAVQEAREKVAKLVN-GGGGTVVFTSGATEANNLAIIGYAMRNARKGKHILVSAVEHMSVINPAKFLQKQGFEVEYIPVGKYGEVDVSFIDQ---KLRDDTILVSVQHANNEIGTIQPVEEISEVLAG-KAALHIDATASVGQIEVDVEKIGADMLTISSNDIYGPKGVGALWIRKEAKLQPVILGGGQENGLRSGSENVPSIVGFGKAAE-----ITAMEWREEAERLRRLRDRIIDNVLKIEESYLNGHPEKRLPNNVNVRFSYIEGESIVLSLDMAGIQASTG--------QPSHVLMACGLKHEEAHGTLLLTLGRYNTDEDVDRLLEVLPGVIERLRSMSP-

General information: TITO was launched using: RESULT: Template: 4HVK.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -170940 for 3122 contacts (-54.8/contact) + 2D Compatibility (PS) -38284 + (NN) -14411 + (LL) 2228 1D Compatibility (HY) -24000 + (ID) 6100 Total energy: -251507.0 ( -80.56 by residue) QMean score : 0.529

(partial model without unconserved sides chains): PDB file : Tito_4HVK.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4HVK-query.scw PDB file : Tito_Scwrl_4HVK.pdb: