Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWA----VSGDSVQNHIDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS 2WWV Chain:D ((5-93)) -HIYLFSSAGMSTSLLVSKMRAQAEKYEVPVIIEAFPETLAGEKGQN----ADVVLLGPQIAYMLPEIQRLLPNK--PVEVIDSLLYGKVDGLGVL----------

General information: TITO was launched using: RESULT: Template: 2WWV.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain D - contact count / total energy / energy per contact / energy per residue : 335 -36795 -109.84 -432.88 target 2D structure prediction score : 0.68 Monomeric hydrophicity matching model chain D : 0.80 3D Compatibility (PKB) : -109.84 2D Compatibility (Sec. Struct. Predict.) : 0.68 1D Compatibility (Hydrophobicity) : 0.80 QMean score : 0.469

(partial model without unconserved sides chains): PDB file : Tito_2WWV.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2WWV-query.scw PDB file : Tito_Scwrl_2WWV.pdb: