Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEAVGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVIVVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDTKKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDENSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQTIKIVNKKEEKSS 4I6R Chain:A ((25-76)) MTQEDLAYKSNLDRTYISGIERNSRN------LTIKSLELIMKGLEVSDVVFFEMLIK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

General information: TITO was launched using: RESULT: Template: 4I6R.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 127 -16596 -130.67 -319.14 target 2D structure prediction score : 0.79 Monomeric hydrophicity matching model chain A : 0.61 3D Compatibility (PKB) : -130.67 2D Compatibility (Sec. Struct. Predict.) : 0.79 1D Compatibility (Hydrophobicity) : 0.61 QMean score : 0.706

(partial model without unconserved sides chains): PDB file : Tito_4I6R.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4I6R-query.scw PDB file : Tito_Scwrl_4I6R.pdb: