Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAMLQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKAMFYGAEFKEILDEV-LPEL----SSL-CVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDTALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALIC--IMLGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEK--HQTDLSSLVILMTGGTKVPSSLISRYLD-IGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPV-AGVKVKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQ-NGWFRTGDSGYVDEDGFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVKNGGQRITEEDVIAFCKER-LSAYKIPE-VEFVNELPKNNLGKVKKDVLRNQAVHS 4IZ6 Chain:A ((57-554)) ---------------SDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSG---EHNLQDAINHPAEDFTATPSPADEVAYFQLSGG-TGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAE-GNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKEP--LRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWL---

General information: TITO was launched using: RESULT: Template: 4IZ6.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 2762 -279746 -101.28 -585.24 target 2D structure prediction score : 0.58 Monomeric hydrophicity matching model chain A : 0.74 3D Compatibility (PKB) : -101.28 2D Compatibility (Sec. Struct. Predict.) : 0.58 1D Compatibility (Hydrophobicity) : 0.74 QMean score : 0.507

(partial model without unconserved sides chains): PDB file : Tito_4IZ6.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4IZ6-query.scw PDB file : Tito_Scwrl_4IZ6.pdb: