Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVKGYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKLQLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQKTFKKMNDKHVDTAIMEVSSHAL-SLGR-VHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAKSLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVT-AAHISTYGIKN-DADVMAKNISITAQGTSFDLVTNKGTKH-ITMSLVGQFNVYNVLAAVATCIAAGI-PFEIITEAVEELHGVRGRFELVNQQQEFPVIVD-YAHTPDSLENVLETCRDMTEGKLFVVVGCG---GDRDKTKRPKMAKIAVE-LADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANA--KKGDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS 1GG4 Chain:A ((4-439)) VTLSQLTDILNGEL---QGADITLDAVTTDTRKLTPGCLFVALKGERFDAHDFADQAKAGGAGALLVSRPLDIDLPQLIVKDTRLAFGELAAWVRQQV--PARVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGV---------PM--TLLR----L-TPEYDYAVIELGANHQGEIAWTVSLTRPEAALVNNLA--------SLAGVAKAKGEIFSGLPEN------GIAIMNADNNDWLNWQSVIGSRKVWRFSPNAANSDFTATNIHVTSHGTEFTLQTPT-GSVDVLLPLPGRHNIANALAAAALSMSVGATL-DAIKAGLANLKAVPGRLFPIQLAENQLLLDDSYNANVGSMTAAVQVLAEMP-GYRVLVVGDMAELGAESEACHVQVGEAAKAAGIDRVLSVGKQSH-----AISTAS----G--VGEHFADKTALITRLKLLIAEQQVITILVKGSRSAAM------------------------------

General information: TITO was launched using: RESULT: Template: 1GG4.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 2438 -285283 -117.02 -687.43 target 2D structure prediction score : 0.54 Monomeric hydrophicity matching model chain A : 0.74 3D Compatibility (PKB) : -117.02 2D Compatibility (Sec. Struct. Predict.) : 0.54 1D Compatibility (Hydrophobicity) : 0.74 QMean score : 0.541

(partial model without unconserved sides chains): PDB file : Tito_1GG4.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1GG4-query.scw PDB file : Tito_Scwrl_1GG4.pdb: