Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEKIESVLN-EPMRIICTNGTISQ--------LRLEELADE---LYDKDVYILVDADESGEKLRKQLKREFNE--ACHLHVDRAY---KEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV 3VDP Chain:A ((90-210)) --------------------------NRDHSTICVVSHPMDVVAMEKVKEYKG-VYHVLHGVISPIEGVGPEDIRIKELLERVRDGSVKEVILATNPDIEGEATAMYIAKLLKPFGVKVTRIAHGIPVGGDLEYTDVVTLSKALEGRR---------------

General information: TITO was launched using: RESULT: Template: 3VDP.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 393 -15578 -39.64 -149.79 target 2D structure prediction score : 0.53 Monomeric hydrophicity matching model chain A : 0.59 3D Compatibility (PKB) : -39.64 2D Compatibility (Sec. Struct. Predict.) : 0.53 1D Compatibility (Hydrophobicity) : 0.59 QMean score : 0.425

(partial model without unconserved sides chains): PDB file : Tito_3VDP.pdb: (Unconserved sides chains are recalculated) : Sequence: align-3VDP-query.scw PDB file : Tito_Scwrl_3VDP.pdb: