Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVKGYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKLQLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQKTFKKMNDKHVDTAIMEVSSHAL-SLGRVHG-CDYDIAVFTNLTQDHLDYHKTMDEYRHAKSLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISITAQGTSFDLVTNKGTKH-ITMSLVGQFNVYNVLAAVATCIAAGI-PFEIITEAVEELHGVRGRFELVNQQQEFPVIVD-YAHTPDSLENVLETCRDMT---EGKLFVVVGCG---GDRDKTKRPKMAKIAVE-LADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIA------NREQAIFFAIANAKKGDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS 3ZM6 Chain:A ((3-448)) LTIHEIAQVVGAKNDISIFEDTQLEKAEFDSRLIGTGDLFVPLKGA-RDGHDFIETAFENGAAVTLSEKE-VSNHPYILVDDVLTAFQSLASYYLEKT--TVDVFAVTGSNGKTTTKDMLAHLLSTRYKTYKTQGNYNNEIGL---------PY--TVL----HM-PEGTEKLVLEMGQDHLGDIHLLSELARPKTAIVTLVGEAHLAFFKDRSEIAKGKMQIADGMASG-------SLLLAPADPIVEDYLPI-DKKVVRFGQG--AELEITDLVERKDSLTFKANF---LEQALDLPVTGKYNATNAMIASYVALQEGVSE-EQIRLAFQHLELTRNRTEWKKAANGADILSDVYNANPTAMKLILETFSAIPANEGGKKIAVLADMKELGDQSVQLHNQMILSLSPDVLDIVIFYGEDIA-----QLAQLASQMFPIGHVYYFKKTEDQDQFEDLVKQVKESLGAHDQILLKGSNSMNLAKL---------------------------

General information: TITO was launched using: RESULT: Template: 3ZM6.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 2396 -258539 -107.90 -604.06 target 2D structure prediction score : 0.57 Monomeric hydrophicity matching model chain A : 0.71 3D Compatibility (PKB) : -107.90 2D Compatibility (Sec. Struct. Predict.) : 0.57 1D Compatibility (Hydrophobicity) : 0.71 QMean score : 0.408

(partial model without unconserved sides chains): PDB file : Tito_3ZM6.pdb: (Unconserved sides chains are recalculated) : Sequence: align-3ZM6-query.scw PDB file : Tito_Scwrl_3ZM6.pdb: