Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEILAEGPENALQSFVEAVKNGSP-FSKVTDISVTESRSLEGHHRFSIVYS 3VTH Chain:A ((13-98)) ----QINIFGIVQGVGFRPFVFNIAQKYNLKGIVYNNSSG-LYIEVEGEEKDIEAFIREIKENPPSLSVIDEIQVREVEVKE-YKDFKIVGS

General information: TITO was launched using: RESULT: Template: 3VTH.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 360 -49344 -137.07 -580.51 target 2D structure prediction score : 0.48 Monomeric hydrophicity matching model chain A : 0.73 3D Compatibility (PKB) : -137.07 2D Compatibility (Sec. Struct. Predict.) : 0.48 1D Compatibility (Hydrophobicity) : 0.73 QMean score : 0.520

(partial model without unconserved sides chains): PDB file : Tito_3VTH.pdb: (Unconserved sides chains are recalculated) : Sequence: align-3VTH-query.scw PDB file : Tito_Scwrl_3VTH.pdb: