Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MERKTVLVIADLGGCPPHMFYKSAAEKYNLVSFIPRPFAITASHAALIEKYSVAVIKDKDYFKSLADFEHPDSIYWAHEDHDKPEEEVVEEIVKVAGMFAVDAITTNNELF-IAPMAKACERLGLR--GAGVQAAENARDKNKMRAAFNRAGVKSIKNKRVTTLEDFRAALQEIGTPLILKPTYLASSIGVTLIKEMETAEAEFNRVNEYLKSINVPKAVTFEAPFIAEEFLQGEYDDWYETSGYSDYISIEGIMADGEYFPVAIHDKTPQ-------IGFTETSHITPSIL-DDDAKRKIV-EAAKK---ANEGLGLE-NCATHTEIKLMKNREAGLIESAARFAGWNMIPNIKKVFGVDMAQLLLDVLCFGKEADLPKGLLEQEPCYVADCHLYPQHF-KENGQLPETAVDFVIESIDIPDGVLKGDTEIVSFS-AAEAGTSVDLRLFEAFNSIAAFELKGSNSGDVAESIKQIQQQAKLTAKYALPV 2YW2 Chain:A ((1-405)) ---MKVLVVGN-GGREHAIAWKVAQSP-LVK-----ELYVAK-GNAGIWE-------------------IAKRV-DISP---TDVEKLAEFA----KNEGVDFTIVGPEAPLVEGIVDEFEKRGLKIFGPNKEAAKLEGSKAFAKTFMKKYGIPTARYEVFTDFEKAKEYVEKVGAPIVVKADGLAAGKGAVVCETVEKAIETLDRFLNKK-IFGKSS-----ERVVIEEFLEGEE------------ASYIVMINGDRYVPLPTSQDHKRLLDEDKGPNTGGMGAYSPTPVINEEVEKRIREEIVERVIKGLKEEGIYYRGFLYAGLMITK-EGPKVLEFNVRLGDPEAQ-PILMRVKNDFLETLLNFYEGKDVHIKEDER------------YALDVVLASRGY-PEKPETGKII--HGLDYLKSMEDVVVFHAGTKKEGNFTVT--SGGRVLNVCAY--GKTLKEAKERAYEAIRYVCF--------

General information: TITO was launched using: RESULT: Template: 2YW2.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 2362 44542 18.86 115.09 target 2D structure prediction score : 0.54 Monomeric hydrophicity matching model chain A : 0.63 3D Compatibility (PKB) : 18.86 2D Compatibility (Sec. Struct. Predict.) : 0.54 1D Compatibility (Hydrophobicity) : 0.63 QMean score : 0.380

(partial model without unconserved sides chains): PDB file : Tito_2YW2.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2YW2-query.scw PDB file : Tito_Scwrl_2YW2.pdb: