Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MAVTYWTGENLTLRAIQPEDIVIFDSLDDEILRNMDSLHFPRSANNMREWVEEQLEKDEFRFIAVESDNNIVGMIETFDCDRKNGTFGY-YLAVFEPYRGKGFAKEMILMVLRFFFLELAYQKVNTTVYSFNNPSIRLHEKLGFMKEGQLRKIIFT-KGAYYDGICFGMTREEFELNHG------ 1YRE Chain:A ((13-195)) -LPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGR-ALPLAVRLGVQLVGTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRNHRRLAGGRLDDTFVYSITDHEWPQVKAALEASF

General information: TITO was launched using: RESULT: Template: 1YRE.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 806 -53557 -66.45 -306.04 target 2D structure prediction score : 0.63 Monomeric hydrophicity matching model chain A : 0.67 3D Compatibility (PKB) : -66.45 2D Compatibility (Sec. Struct. Predict.) : 0.63 1D Compatibility (Hydrophobicity) : 0.67 QMean score : 0.521

(partial model without unconserved sides chains): PDB file : Tito_1YRE.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1YRE-query.scw PDB file : Tito_Scwrl_1YRE.pdb: