Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDS-----IPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 4EOK Chain:A ((4-299)) MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRL----EGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLSMDLKDFMDASALTGIP------LPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL

General information: TITO was launched using: RESULT: Template: 4EOK.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -164228 for 2299 contacts (-71.4/contact) + 2D Compatibility (PS) -29776 + (NN) -6664 + (LL) 316 1D Compatibility (HY) -40000 + (ID) 9800 Total energy: -250152.0 ( -108.81 by residue) QMean score : 0.480

(partial model without unconserved sides chains): PDB file : Tito_4EOK.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4EOK-query.scw PDB file : Tito_Scwrl_4EOK.pdb: