Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHNKHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDATCPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVG--VAPE-IVHLVETEEDVKNLDIQS-EKLIVTNQTTMSQWDVHDIMELVKEKYPHV--EYHQEICLATQVRQEAVSEQAKKADLTIVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPITKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN 3UV6 Chain:B ((9-293)) MQILLANPRGFCAGVDRAISIVENAL--AIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE-----QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM-GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL---------------------------

General information: TITO was launched using: RESULT: Template: 3UV6.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain B - contact count / total energy / energy per contact / energy per residue : 1579 -27511 -17.42 -98.61 target 2D structure prediction score : 0.67 Monomeric hydrophicity matching model chain B : 0.79 3D Compatibility (PKB) : -17.42 2D Compatibility (Sec. Struct. Predict.) : 0.67 1D Compatibility (Hydrophobicity) : 0.79 QMean score : 0.603

(partial model without unconserved sides chains): PDB file : Tito_3UV6.pdb: (Unconserved sides chains are recalculated) : Sequence: align-3UV6-query.scw PDB file : Tito_Scwrl_3UV6.pdb: