Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVNRKCEHGVILKVITTNICGSD-QHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGDIVSVPFNIACGRCVMCKTQKTHVCL----NVNPDRPGSAYGYVDMGG----WVGGQSEYVMVPYADFQLLVFPDKEQALEKILDLTMLSDIFPTGFHGAY-TAGVQTGSTVYIAGAGPVGLAAAHSAQLLGASTVIVGDLNEDRLAQARSFGC-ETVNVQKHDRLGEQIEQILGEPT---VDAAVDCVGFEASGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIRFGLGWAKAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFDKGAAKKFVIDPHGTLK 1CDO Chain:B ((6-271)) ------------VIKCKAAVAWE-ANKPLVIEEIEVDVPHANEIR-------IKIIATGVCHTDLYHLFEGKHKDGFPVVLGHEGAGIVESVGPGVTEFQPGEKVIPLFISQCGECRFCQSPKTNQCVKGWANESPDVMSPKETRFTCKGRKVLQFLGTSTFSQYTVVNQIAVAKIDPSAPLDTV---CLLGCGVSTGFGAAVNTAKVEPGSTCAVFGLGAVGLAAVMGCHSAGAKRIIAVDLNPDKFEKAKVFGATDFVNPNDHS---EPISQVLSKMTNGGVDFSLECVG----------------------------------------------------------------------------------------------------------------------------------

General information: TITO was launched using: RESULT: Template: 1CDO.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain B - contact count / total energy / energy per contact / energy per residue : 1348 -29775 -22.09 -118.15 target 2D structure prediction score : 0.56 Monomeric hydrophicity matching model chain B : 0.66 3D Compatibility (PKB) : -22.09 2D Compatibility (Sec. Struct. Predict.) : 0.56 1D Compatibility (Hydrophobicity) : 0.66 QMean score : 0.439

(partial model without unconserved sides chains): PDB file : Tito_1CDO.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1CDO-query.scw PDB file : Tito_Scwrl_1CDO.pdb: