Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MRQSLTLIPTLREVPADAEAKSHQLLLRA-GFIR--QNTSGVYSYMPLAYKVIQNIQQIVREEM-EKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGREFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPR-FGLLRGREFIMKDAYSFHASAESLDETYQKMYEAYSNIFAR-CGINVRPVIADSGAMGGKDTHEFMALSAIGEDTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEACIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVGPVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDPSPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPML---MGCYGIGVSRTLSAIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKA--------------EGYEVLYDDRAERAGVKFADSDLIGLPIRITVGKRA-DEGIVEVKIRQTGES-TEISVDELSAFISKQ 3UH0 Chain:A ((34-453)) -------------------ATMTSMVSQRQDLFMTDPLSPGSMFFLPNGAKIFNKLIEFMKLQQKFKFGFNEVVTPLIYKKTLWEKSGHWENYADDMFKVET----EYGLKPMNCPGHCLIFGKKDRSYNELPLRFSDFSPLHRNEASGALSGLTRLRKFHQDDGHIFCTP-SQVKSEIFNSLKLIDIVYNKIFPFV------------AE-SNYFINFSTRP----------------DHFIG-------DL-----------KVWNH-------------------------------------AEQVLKEILEESGKPW-------KLNPGDGAFYGPK-----L---------------------DIMV--------------TD-----------------HLRKTHQVATI-QLDFQLPERFDLKFKDQDNSYKRPIMIHRATFG-SIERFMALLIDSNE----GRWPFWLNPYQAVIIPVNTKNVQQLDMCTALQKKLRNELEADDMEPVPLNDWHFNVDLDIRNEPVGYRIKSAILKNYSYLIIVGDEEVQLQKYNIRERDNRKSFEKLTMSQIWEKFI--

General information: TITO was launched using: RESULT: Template: 3UH0.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1921 -146040 -76.02 -380.31 target 2D structure prediction score : 0.51 Monomeric hydrophicity matching model chain A : 0.67 3D Compatibility (PKB) : -76.02 2D Compatibility (Sec. Struct. Predict.) : 0.51 1D Compatibility (Hydrophobicity) : 0.67 QMean score : 0.473

(partial model without unconserved sides chains): PDB file : Tito_3UH0.pdb: (Unconserved sides chains are recalculated) : Sequence: align-3UH0-query.scw PDB file : Tito_Scwrl_3UH0.pdb: