Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEDFLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFN----LKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPF-DDTDIPKMLWQQQKGVSFPTHL--SISADCQDLLKRLLEPDMILRPSIEEVSWHPWLAST 4MVF Chain:A ((55-314)) -----LEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIK--EEKKDRLKNINRFF-QEIEIMKKLDHPNIVKLYETYEN-DNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNL--------------------------KYD-KKCDIWSSGVIMYTLLCGYPPFY----------------CFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALNHPWITQM

General information: TITO was launched using: RESULT: Template: 4MVF.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -129023 for 1625 contacts (-79.4/contact) + 2D Compatibility (PS) -22969 + (NN) -9121 + (LL) 3364 1D Compatibility (HY) -20400 + (ID) 4300 Total energy: -182449.0 ( -112.28 by residue) QMean score : 0.464

(partial model without unconserved sides chains): PDB file : Tito_4MVF.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4MVF-query.scw PDB file : Tito_Scwrl_4MVF.pdb: