Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQK------ASL---EAAGAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAIAG-IKRFIMVSALQAHNRENWN-EALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPGTG------------TVSAAKD--LERGFISRDDVAKTVIASLDEKNTENRAFDLT-E-GDTPIAEALKKL 1QYC Chain:A ((5-230)) SRILLIGATGYIGRHVAKASLDLG-HPTFLLVRESTASSNSEKAQLLESFKASGANIVHGSID-DHASLVEAVKNVDVVISTVGSLQ-----------IESQVNIIKAIKEVGTVKRFFP-SEFGNDVDNVHAVEPAKSVFEVKAKVRRAIEAEGIPYTYVSSNCFAGYFLRSLAQAGLTAPPRDKVVILGDGNARVVFVKEEDIGTFTIKAVDDPRTLNKTLYLRLPANTLSLNELVAL-

General information: TITO was launched using: RESULT: Template: 1QYC.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 978 -120982 -123.70 -607.95 target 2D structure prediction score : 0.61 Monomeric hydrophicity matching model chain A : 0.69 3D Compatibility (PKB) : -123.70 2D Compatibility (Sec. Struct. Predict.) : 0.61 1D Compatibility (Hydrophobicity) : 0.69 QMean score : 0.468

(partial model without unconserved sides chains): PDB file : Tito_1QYC.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1QYC-query.scw PDB file : Tito_Scwrl_1QYC.pdb: