Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEDFLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRF-LPRELQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFN----LKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVL--QGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSF----PTHLSISADCQDLLKRLLEPDMILRPSIEEVSWHPWLAST 2YIR Chain:A ((8-278)) -----LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISK----------LNVETEIEILKKLNHPCIIKIKNFFDAEDYYI--VLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS--LMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDE

General information: TITO was launched using: RESULT: Template: 2YIR.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -136674 for 1775 contacts (-77.0/contact) + 2D Compatibility (PS) -26445 + (NN) -12568 + (LL) 1468 1D Compatibility (HY) -20800 + (ID) 4850 Total energy: -199869.0 ( -112.60 by residue) QMean score : 0.424

(partial model without unconserved sides chains): PDB file : Tito_2YIR.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2YIR-query.scw PDB file : Tito_Scwrl_2YIR.pdb: