Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MGKGDVLEAAPTTTAYHSLMDEYGYEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKYLINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFD---DTNLKKLLRETQKEVTFPANHTISQECKNLILQMLRQATKRATILDIIKDSWVLKFQPEQPTHEIRLLEAMCQLHNTTKQHQSLQITT 4RVL Chain:A ((9-264)) ------------------------WDLVQTLG------VQLAVNRVTEEAVAVKIVDMK-------N--IKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVF-------------RYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGA---------------------------

General information: TITO was launched using: RESULT: Template: 4RVL.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -134724 for 1871 contacts (-72.0/contact) + 2D Compatibility (PS) -24829 + (NN) -1095 + (LL) 3668 1D Compatibility (HY) -15200 + (ID) 4050 Total energy: -176230.0 ( -94.19 by residue) QMean score : 0.350

(partial model without unconserved sides chains): PDB file : Tito_4RVL.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4RVL-query.scw PDB file : Tito_Scwrl_4RVL.pdb: