Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASRMEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNIDGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLE-REVPECTAAGNNGDICGTVLKTDVVLFGDAVMH--FDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIINLEP--TYCDSLFDMVIHQKIGEFARSLGMKK 1ICI Chain:A ((14-242)) -EKLLKTIAESKYLVALTGAGVSAESGIPTFRGKDGLWNRYRPE-ELANPQAFAKDPEKVWKWYA--WRMEKVFNAQPNKAHQAFAELERLGVLKCLITQNVDDLHERAGSRNVIHLHGSLRVVRCTSCNNSFEVESAPKIPPLPKC-------DKCGSLLRPGVVWFGEMLPPDVLDRAMREVERADVIIVAGTSAVVQPAASLP---LIVKQRGGAIIEINPDETPLTPIADYSLRGKAGE---------

General information: TITO was launched using: RESULT: Template: 1ICI.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1169 -112961 -96.63 -504.29 target 2D structure prediction score : 0.59 Monomeric hydrophicity matching model chain A : 0.77 3D Compatibility (PKB) : -96.63 2D Compatibility (Sec. Struct. Predict.) : 0.59 1D Compatibility (Hydrophobicity) : 0.77 QMean score : 0.335

(partial model without unconserved sides chains): PDB file : Tito_1ICI.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1ICI-query.scw PDB file : Tito_Scwrl_1ICI.pdb: