Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKIDSWLNDRLDIAKEAGVHRNL---RSMNGAPVPERNIDGENQTVWSSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKRTEAALLFSSGYLANVGVLSSLPEKEDVILSDQLNHASIIDGCRLSKADTVVYRHIDMNDLENKLNETQ--RYQRRFIVTDGVFSMDGTIVPLDQIISLAKRYHAFVVVDDAHATGVLGDSGRGTSEYFGV--YPDIVIGTLSKAVGT-EGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAAAHEAFNIRT------------------SLKNMGYVVKGDHTPIIPVVIGDAHKTVIFAEKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDDLLKTFHSIGKELHII 1FC4 Chain:A ((9-399)) ---YQQLTNDLETARAEGLFKEERIITSAQQADIT--VADGSHVINFCANNYLGLANHPDLIAAAKAGMDSHGFGMASVRFICGTQDSHKELEQKLAAFLGMEDAILYSSCFDANGGLFETLLGAEDAIISDALNHASIIDGVRLCKAKRYRYANNDMQELEARLKEAREAGARHVLIATDGVFSMDGVIANLKGVCDLADKYDALVMVDDSHAVGFVGENGRGSHEYCDVMGRVDIITGTLGKALGGASGGYTAARKEVVEWLRQRSRPYLFSNSLAPAIVAASIKVLEMVEAGSELRDRLWANARQFREQMSAAGFTLAGADHAIIPVMLGDAVVAQKFARELQKEGIYVTGFFYPVVPKGQARIRTQMSAAHTPEQITRAVEAFTRIGKQLGV-

General information: TITO was launched using: RESULT: Template: 1FC4.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 2046 -2086 -1.02 -5.71 target 2D structure prediction score : 0.70 Monomeric hydrophicity matching model chain A : 0.80 3D Compatibility (PKB) : -1.02 2D Compatibility (Sec. Struct. Predict.) : 0.70 1D Compatibility (Hydrophobicity) : 0.80 QMean score : 0.499

(partial model without unconserved sides chains): PDB file : Tito_1FC4.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1FC4-query.scw PDB file : Tito_Scwrl_1FC4.pdb: