Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MAIVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYMGGYKLCKQLIETLVESMGITVPVAIHLDHGHYDDALEC----IEVGYTSIMFDGSHLPVEENLEKAREVVAKAHAKGISVEAEVGTIGGEEDGIVGKGELAPIEDAKAMVE-TGIDFLAAGIGNIHGPYPANWEG-LDLDHLKKLTEAVPGFPIVLHGGSGIPDD---------------------QIQEAIKLGVAKVNVNTECQLAFCQATRDYAVEFNANEAEYMKKKLFDPRKFLKPGFDAITEAVEERIDVFGSANKA 2ISW Chain:A ((2-307)) -PLCTLRQMLGEARKHKYGVGAFNVNNMEQIQGIMKAVVQLKSPVILQCSRGALKYSDMIYL-KKLCEAALEKHP-DIPICIHLDHG---DTLESVKMAIDLGFSSVMIDASHHPFDENVRITKEVVAYAHARSVSVEAELGTL----------VQLTEPQDAKKFVELTGVDALAVAIGTSHGAYKFKS--RLAIDRVKTISD-LTGIPLVMHGSSSVPKDVKDMINKYGGKMPDAVGVPIESIVHAIGEGVCKINVDSDSRMAMTGAIRKVFVEHPEK---------FDPRDYLGPGRDAITEMLIPKIKAFGSAGHA

General information: TITO was launched using: RESULT: Template: 2ISW.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -129839 for 2296 contacts (-56.6/contact) + 2D Compatibility (PS) -30013 + (NN) -22829 + (LL) 1528 1D Compatibility (HY) -21600 + (ID) 6000 Total energy: -208753.0 ( -90.92 by residue) QMean score : 0.611

(partial model without unconserved sides chains): PDB file : Tito_2ISW.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2ISW-query.scw PDB file : Tito_Scwrl_2ISW.pdb: