Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEDFLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRF-LPRELQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFN----LKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVL--QGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSF----PTHLSISADCQDLLKRLLEPDMILRPSIEEVSWHPWLAST 4BDF Chain:A ((14-284)) -----LRDEYIMSKTLG----GEVKLAFERKTCKKVAIKIISK-----------NVETEIEILKKLNHPCIIKIKNFFDAEDYYI--VLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGET--SLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDE

General information: TITO was launched using: RESULT: Template: 4BDF.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -133522 for 1747 contacts (-76.4/contact) + 2D Compatibility (PS) -25882 + (NN) -12451 + (LL) 1616 1D Compatibility (HY) -20000 + (ID) 4800 Total energy: -195039.0 ( -111.64 by residue) QMean score : 0.436

(partial model without unconserved sides chains): PDB file : Tito_4BDF.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4BDF-query.scw PDB file : Tito_Scwrl_4BDF.pdb: